Antibodies under a microscope

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  • Category A

    • Original source/host: Naïve (human-derived B cell) or synthetic, natural or consensus framework (any species, published framework sequences) antibody or mimetic
    • Discovery method: Non-immunisation based in vitro display selection of antibody or mimetic
    • Production: Recombinant expression with no use of animal-derived biomaterials in production or final formulation
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  • Category B

    • Original source/host: Animal (historic hybridoma) OR naïve, non-immunised animal B cell-derived in vitro antibody display library
    • Discovery method: immunisation pre-2020 OR in vitro display selection of antibodies
    • Production: Recombinant expression with no use of animal-derived biomaterials in production or final formulation
    • Recombinantly reformatted hybridomas are included as they align with the May 2020 EURL ECVAM recommendation, which permits continued use of existing, sequenced, and well-characterised hybridomas to produce recombinant monoclonal antibodies in vitro, as animals are no longer directly involved
    • Naïve, non-immunised animal B cell-derived in vitro antibody display libraries align with the May 2020 EURL ECVAM recommendation to no longer authorise the development and production of antibodies through animal immunisation
    Search

  • Category C

    • Original source/host: Naïve (human-derived B cell) or synthetic, natural or consensus framework (any species, published framework sequences) antibody or mimetic
    • Discovery method: Non-immunisation based in vitro display selection of antibody or mimetic
    • Production: Recombinant expression ; animal-derived biomaterials used in production or final formulation
    Search

  • Category D

    • Original source/host: Animal OR naïve, non-immunised animal B cell-derived in vitro antibody display library
    • Discovery method: immunisation pre-2020 OR in vitro display selection of antibodies
    • Production: Recombinant expression ; animal-derived biomaterials used in production or final formulation
    Search

  • Category E

    • Original source/host: Animal
    • Discovery method: immunisation-based selection post 2020
    • Production: Recombinant expression with no use of animal-derived biomaterials in production or final formulation
    Search

  • Category F

    • Original source/host: Animal
    • Discovery method: immunisation-based selection post 2020
    • Production: Recombinant expression with animal-derived biomaterials used in production or final formulation
    Search

  • Category G

    • Original source/host: Unknown
    • Discovery method: Unknown
    • Production: Recombinant expression with no use of animal-derived biomaterials in production or final formulation
    Search

1201-1210 of 1245 results

Catalogue Number:

DHC34203

Category:

G

Research Grade Telisotuzumab

Targets: Tyrosine-protein kinase Met, Hepatocyte growth factor receptor, Proto-oncogene c-Met, Scatter factor receptor, HGF receptor, SF receptor, HGF/SF receptor, MET
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG1-kappa
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Unknown
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Unknown discovery source/method, In vitro recombinant expression

Catalogue Number:

DHC27703

Category:

G

Research Grade Teplizumab

Targets: T3E, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T-cell surface glycoprotein CD3 epsilon chain
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG1-kappa
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Unknown
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Unknown discovery source/method, In vitro recombinant expression

Catalogue Number:

DHJ95301

Category:

A

Research Grade Tepoditamab

Targets: CLEC12A, DCAL2, Dendritic cell-associated lectin 2, CLL-1, Myeloid inhibitory C-type lectin-like receptor, C-type lectin domain family 12 member A, CLL1, DCAL-2, C-type lectin-like molecule 1, MICL, CD371, T3E, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T-cell surface glycoprotein CD3 epsilon chain
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG1-kappa
Host Species: Human
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Naive display libraries derived from human B cells
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Animal-free discovery, In vitro recombinant expression

Catalogue Number:

DHC29903

Category:

A

Research Grade Teprotumumab

Targets: CD221, Insulin-like growth factor 1 receptor, IGF1R, Insulin-like growth factor I receptor, IGF-I receptor
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG1-nd
Host Species: Human
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Naive display libraries derived from human B cells
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Animal-free discovery, In vitro recombinant expression

Catalogue Number:

DHJ36101

Category:

A

Research Grade Tezepelumab

Targets: TSLP, Thymic stromal lymphopoietin
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG2-lambda
Host Species: Human
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Naive display libraries derived from human B cells
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Animal-free discovery, In vitro recombinant expression

Catalogue Number:

DHC83402

Category:

G

Research Grade Theralizumab

Targets: CD28, TP44, T-cell-specific surface glycoprotein CD28
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG4
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Unknown
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Unknown discovery source/method, In vitro recombinant expression

Catalogue Number:

DHC82403

Category:

G

Research Grade Tilavonemab

Targets: MAPTL, Paired helical filament-tau, MTBT1, Microtubule-associated protein tau, TAU, Neurofibrillary tangle protein, MAPT, PHF-tau
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG4-kappa
Host Species: Other
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Unknown
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Unknown discovery source/method, In vitro recombinant expression

Catalogue Number:

DHJ63102

Category:

G

Research Grade Tildrakizumab

Targets: SGRF, IL-23-A, IL-23 subunit alpha, Interleukin-23 subunit p19, IL23A, Interleukin-23 subunit alpha, IL-23p19
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG1-kappa
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Unknown
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Unknown discovery source/method, In vitro recombinant expression

Catalogue Number:

DHD89502

Category:

G

Research Grade Tilvestamab

Targets: UFO, AXL oncogene, Tyrosine-protein kinase receptor UFO, AXL
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG1-kappa
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Unknown
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Unknown discovery source/method, In vitro recombinant expression

Catalogue Number:

DHE25601

Category:

G

Research Grade Tinurilimab

Targets: Normal cross-reacting antigen, Carcinoembryonic antigen-related cell adhesion molecule 6, CEACAM6, CD66c, NCA, Non-specific crossreacting antigen
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG1-kappa
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Unknown
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Unknown discovery source/method, In vitro recombinant expression