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  • Category A

    • Original source/host: Naïve (human-derived B cell) or synthetic, natural or consensus framework (any species, published framework sequences) antibody or mimetic
    • Discovery method: Non-immunisation based in vitro display selection of antibody or mimetic
    • Production: Recombinant expression with no use of animal-derived biomaterials in production or final formulation
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  • Category B

    • Original source/host: Animal (historic hybridoma) OR naïve, non-immunised animal B cell-derived in vitro antibody display library
    • Discovery method: immunisation pre-2020 OR in vitro display selection of antibodies
    • Production: Recombinant expression with no use of animal-derived biomaterials in production or final formulation
    • Recombinantly reformatted hybridomas are included as they align with the May 2020 EURL ECVAM recommendation, which permits continued use of existing, sequenced, and well-characterised hybridomas to produce recombinant monoclonal antibodies in vitro, as animals are no longer directly involved
    • Naïve, non-immunised animal B cell-derived in vitro antibody display libraries align with the May 2020 EURL ECVAM recommendation to no longer authorise the development and production of antibodies through animal immunisation
    Search

  • Category C

    • Original source/host: Naïve (human-derived B cell) or synthetic, natural or consensus framework (any species, published framework sequences) antibody or mimetic
    • Discovery method: Non-immunisation based in vitro display selection of antibody or mimetic
    • Production: Recombinant expression ; animal-derived biomaterials used in production or final formulation
    Search

  • Category D

    • Original source/host: Animal OR naïve, non-immunised animal B cell-derived in vitro antibody display library
    • Discovery method: immunisation pre-2020 OR in vitro display selection of antibodies
    • Production: Recombinant expression ; animal-derived biomaterials used in production or final formulation
    Search

  • Category E

    • Original source/host: Animal
    • Discovery method: immunisation-based selection post 2020
    • Production: Recombinant expression with no use of animal-derived biomaterials in production or final formulation
    Search

  • Category F

    • Original source/host: Animal
    • Discovery method: immunisation-based selection post 2020
    • Production: Recombinant expression with animal-derived biomaterials used in production or final formulation
    Search

  • Category G

    • Original source/host: Unknown
    • Discovery method: Unknown
    • Production: Recombinant expression with no use of animal-derived biomaterials in production or final formulation
    Search

1161-1170 of 1245 results

Catalogue Number:

DHE26301

Category:

G

Research Grade Polatuzumab

Targets: B-cell-specific glycoprotein B29, CD79B, B-cell antigen receptor complex-associated protein beta chain, Ig-beta, B29, Immunoglobulin-associated B29 protein, IGB, CD79b
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG1-kappa
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Unknown
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Unknown discovery source/method, In vitro recombinant expression

Catalogue Number:

DHK08301

Category:

G

Research Grade Ponezumab

Targets: AICD-57, A4, Beta-CTF, Protease nexin-II, Gamma-CTF(50), ABPP, S-APP-beta, APP, Abeta40, Abeta42, AID(59), Amyloid intracellular domain 59, AID(57), S-APP-alpha, Gamma-CTF(59), Beta-secretase C-terminal fragment, Amyloid-beta precursor protein, Amyloid precursor protein, Beta-APP42, PreA4, Alzheimer disease amyloid protein, APPI, PN-II, AICD-59, Alpha-secretase C-terminal fragment, Amyloid-beta A4 protein, Amyloid intracellular domain 57, CVAP, Amyloid intracellular domain 50, Beta-APP40, AD1, Cerebral vascular amyloid peptide, AID(50), Alpha-CTF, Gamma-CTF(57), AICD-50
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG2-kappa
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Unknown
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Unknown discovery source/method, In vitro recombinant expression

Catalogue Number:

DHE22002

Category:

G

Research Grade Prasinezumab

Targets: Alpha-synuclein, PARK1, Non-A4 component of amyloid precursor, NACP, Non-A beta component of AD amyloid, SNCA
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG1-kappa
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Unknown
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Unknown discovery source/method, In vitro recombinant expression

Catalogue Number:

DHC35301

Category:

A

Research Grade Pritumumab

Targets: Vimentin, VIM
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG1-nd
Host Species: Human
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Naive display libraries derived from human B cells
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Animal-free discovery, In vitro recombinant expression

Catalogue Number:

DHE16601

Category:

A

Research Grade Ramucirumab

Targets: FLK-1, Kinase insert domain receptor, VEGFR2, Fetal liver kinase 1, CD309, Vascular endothelial growth factor receptor 2, Protein-tyrosine kinase receptor flk-1, FLK1, VEGFR-2, KDR
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG1-kappa
Host Species: Human
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Naive display libraries derived from human B cells
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Animal-free discovery, In vitro recombinant expression

Catalogue Number:

DHD12601

Category:

G

Research Grade Ranibizumab

Targets: Vascular endothelial growth factor A, VPF, VEGFA, VEGF, Vascular permeability factor, VEGF-A
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: Fab-G1-kappa
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Unknown
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Unknown discovery source/method, In vitro recombinant expression

Catalogue Number:

DHD43401

Category:

G

Research Grade Refanezumab

Targets: Myelin-associated glycoprotein, MAG, Siglec-4a, GMA
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG1-kappa
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Unknown
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Unknown discovery source/method, In vitro recombinant expression

Catalogue Number:

DHD30403

Category:

A

Research Grade Relatlimab

Targets: FDC, LAG3, Lymphocyte activation gene 3 protein, CD223, sLAG-3, LAG-3
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG4-kappa
Host Species: Human
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Naive display libraries derived from human B cells
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Animal-free discovery, In vitro recombinant expression

Catalogue Number:

DHD03702

Category:

A

Research Grade Rilotumumab

Targets: SF, HPTA, Hepatopoietin-A, Hepatocyte growth factor, Scatter factor, HGF
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG2-kappa
Host Species: Human
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Naive display libraries derived from human B cells
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Animal-free discovery, In vitro recombinant expression

Catalogue Number:

DHC90705

Category:

G

Research Grade Rituximab

Targets: B-lymphocyte surface antigen B1, Membrane-spanning 4-domains subfamily A member 1, MS4A1, Leukocyte surface antigen Leu-16, B-lymphocyte antigen CD20, Bp35, CD20
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG1-kappa
Host Species: Other
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Unknown
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Unknown discovery source/method, In vitro recombinant expression