Antibodies under a microscope

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  • Category A

    • Original source/host: Naïve (human-derived B cell) or synthetic, natural or consensus framework (any species, published framework sequences) antibody or mimetic
    • Discovery method: Non-immunisation based in vitro display selection of antibody or mimetic
    • Production: Recombinant expression with no use of animal-derived biomaterials in production or final formulation
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  • Category B

    • Original source/host: Animal (historic hybridoma) OR naïve, non-immunised animal B cell-derived in vitro antibody display library
    • Discovery method: immunisation pre-2020 OR in vitro display selection of antibodies
    • Production: Recombinant expression with no use of animal-derived biomaterials in production or final formulation
    • Recombinantly reformatted hybridomas are included as they align with the May 2020 EURL ECVAM recommendation, which permits continued use of existing, sequenced, and well-characterised hybridomas to produce recombinant monoclonal antibodies in vitro, as animals are no longer directly involved
    • Naïve, non-immunised animal B cell-derived in vitro antibody display libraries align with the May 2020 EURL ECVAM recommendation to no longer authorise the development and production of antibodies through animal immunisation
    Search

  • Category C

    • Original source/host: Naïve (human-derived B cell) or synthetic, natural or consensus framework (any species, published framework sequences) antibody or mimetic
    • Discovery method: Non-immunisation based in vitro display selection of antibody or mimetic
    • Production: Recombinant expression ; animal-derived biomaterials used in production or final formulation
    Search

  • Category D

    • Original source/host: Animal OR naïve, non-immunised animal B cell-derived in vitro antibody display library
    • Discovery method: immunisation pre-2020 OR in vitro display selection of antibodies
    • Production: Recombinant expression ; animal-derived biomaterials used in production or final formulation
    Search

  • Category E

    • Original source/host: Animal
    • Discovery method: immunisation-based selection post 2020
    • Production: Recombinant expression with no use of animal-derived biomaterials in production or final formulation
    Search

  • Category F

    • Original source/host: Animal
    • Discovery method: immunisation-based selection post 2020
    • Production: Recombinant expression with animal-derived biomaterials used in production or final formulation
    Search

  • Category G

    • Original source/host: Unknown
    • Discovery method: Unknown
    • Production: Recombinant expression with no use of animal-derived biomaterials in production or final formulation
    Search

1081-1090 of 1245 results

Catalogue Number:

DHD10802

Category:

G

Research Grade Inebilizumab

Targets: CD19, Differentiation antigen CD19, T-cell surface antigen Leu-12, B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG1-kappa
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Unknown
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Unknown discovery source/method, In vitro recombinant expression

Catalogue Number:

DHB94403

Category:

G

Research Grade Infliximab

Targets: TNF, Tumor necrosis factor ligand superfamily member 2, N-terminal fragment, ICD2, NTF, TNF-a, TNF-alpha, Tumor necrosis factor, TNFSF2, TNFA, Cachectin, ICD1
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotypes/Mimetics: IgG1, kappa
Host Species: Other
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Unknown
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Unknown discovery source/method, In vitro recombinant expression

Catalogue Number:

DHC21903

Category:

A

Research Grade Intetumumab

Targets: MSK8, VNRA, Vitronectin receptor, Integrin alpha-V, Vitronectin receptor subunit alpha, CD51, ITGAV, VTNR, GPIIIa, Integrin beta-3, CD61, ITGB3, Platelet membrane glycoprotein IIIa, GP3A
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG1-kappa
Host Species: Human
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Naive display libraries derived from human B cells
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Animal-free discovery, In vitro recombinant expression

Catalogue Number:

DHD17201

Category:

A

Research Grade Ipilimumab

Targets: CD152, Cytotoxic T-lymphocyte protein 4, CTLA-4, CTLA4, Cytotoxic T-lymphocyte-associated antigen 4
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG1-kappa
Host Species: Human
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Naive display libraries derived from human B cells
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Animal-free discovery, In vitro recombinant expression

Catalogue Number:

DHD80902

Category:

A

Research Grade Iratumumab

Targets: CD30L receptor, Ki-1 antigen, CD30, TNFRSF8, D1S166E, Tumor necrosis factor receptor superfamily member 8, Lymphocyte activation antigen CD30
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG1-kappa
Host Species: Human
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Naive display libraries derived from human B cells
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Animal-free discovery, In vitro recombinant expression

Catalogue Number:

DHD80802

Category:

G

Research Grade Isatuximab

Targets: Cyclic ADP-ribose hydrolase 1, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase, T10, 2'-phospho-cyclic-ADP-ribose transferase, CD38, ADPRC 1, ADP-ribosyl cyclase 1, 2'-phospho-ADP-ribosyl cyclase
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG1-kappa
Host Species: Other
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Unknown
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Unknown discovery source/method, In vitro recombinant expression

Catalogue Number:

DHD87601

Category:

G

Research Grade Itolizumab

Targets: TP120, CD6, T12, T-cell differentiation antigen CD6
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG1-kappa
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Unknown
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Unknown discovery source/method, In vitro recombinant expression

Catalogue Number:

DHE43201

Category:

A

Research Grade Ivuxolimab

Targets: ACT35 antigen, TXGP1L, TAX transcriptionally-activated glycoprotein 1 receptor, Tumor necrosis factor receptor superfamily member 4, TNFRSF4, OX40L receptor, CD134
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG2-kappa
Host Species: Human
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Naive display libraries derived from human B cells
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Animal-free discovery, In vitro recombinant expression

Catalogue Number:

DHH28801

Category:

G

Research Grade Ixekizumab

Targets: CTLA-8, Cytotoxic T-lymphocyte-associated antigen 8, IL17, IL-17A, IL17A, CTLA8, IL-17, Interleukin-17A
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG4-kappa
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Unknown
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Unknown discovery source/method, In vitro recombinant expression

Catalogue Number:

DHC21001

Category:

G

Research Grade Labetuzumab

Targets: Meconium antigen 100, CEACAM5, CEA, CD66e, Carcinoembryonic antigen-related cell adhesion molecule 5, Carcinoembryonic antigen
Species Reactivity: Human
Application: Other
Other Application: Research Grade Biosimilar
Type: Primary Recombinant
Isotype/Mimetic: IgG1-kappa
Animal-Derived Biomaterials Used: None
Sequence Available No
Original Discovery Method Unknown
Original Discovery Information Provided On Datasheet No
Antibody/Binder Origins: Unknown discovery source/method, In vitro recombinant expression