Antibodies under a microscope

40543-R033-H

Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-E / Envelope protein (Domain III) Antibody (HRP), Rabbit MAb

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Description

Envelope of Zika virus is responsible for receptor binding and membrane. Analysis of the envelope protein of Zika, from Brazilian Zika SPH215 (KU321639), indicates predicted B and T cell epitopes in peptides that are consistent with those reported for dengue, YFYF and Japanese encephalitis. The envelope Domain II B cell epitope, to which much dengue non-neutralizing cross-reaction is attributed, is also conserved also in Zika virus, consistent with prior field observations of cross-reactivity with dengue and YF. Domain III of the Zika envelope protein, likely the main specific neutralizing domain, is distinct from recent Brazilian dengue isolates and a recent Peruvian YF isolate (GQ379163), 76% of possible major histocompatibility complex class (MHC) I and MHC II binding peptides and potential B cell linear epitopes are unique to Zika virus.

Target

ZIKV-E

Target Alias Name

ZIKV-E

Isotype/Mimetic

Rabbit IgG

Animal-Derived Biomaterials Used

No

Sequence Available

No

Original Discovery Method

Phage display technology

Antibody/Binder Origins

Animal-dependent discovery, post-2020, In vitro recombinant expression

Category: E
Species Reactivity: Other
Application: ELISA
Type: Primary Recombinant
Host Species: Rabbit
Conjugate: HRP
Formulation: 0.2 um filtered solution in PBS