Description
Tri-Methyl-Histone H3 (Lys36) (D5A7) XP® Rabbit mAb (BSA and Azide Free) detects endogenous levels of histone H3 only when tri-methylated on Lys36. The antibody does not cross-react with non-methylated, mono-methylated, or di-methylated Lys36. In addition, the antibody does not cross-react with histone H3 methylated at Lys4, Lys9, Lys27 or histone H4 methylated at Lys20. Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the amino terminus of histone H3 in which Lys36 is tri-methylated.
Target
H3 (Lys36) trimethylate
Target Alias Names
H3C1, H3
Isotype/Mimetic
IgG
Animal-Derived Biomaterials Used
None
Sequence Available
Yes
Original Discovery Method
Immunization
Antibody/Binder Origins
Animal-dependent discovery, post-2020, In vitro recombinant expression