Antibodies under a microscope

110123-R012

Somatostatin Antibody, Rabbit MAb

Description

Somatostatin (SST) is a cyclic peptide that is understood to inhibit the release of hormones and neurotransmitters from a variety of cells by binding to one of five canonical G protein-coupled SST receptors (SSTR1 to SSTR5). Somatostatin (SST) is an inhibitor of the release of somatotropin, glucagon, insulin, gastrointestinal hormones, and other secretory proteins (1). SST is also known as somatotropin release-inhibiting factor (SRIF). SST is a cyclic polypeptide with two biologically active isoforms, SRIF-14 and SRIF-28, of 14 and 28 amino acids, respectively. SST negatively regulates cell proliferation and the release of multiple hormones via activation of its cognate receptors. A variety of SST analogs, some with high affinity and selectivity of receptor subtypes, have been synthesized and developed.

Target

SST

Target Alias Name

SST

Isotype/Mimetic

Rabbit IgG

Animal-Derived Biomaterials Used

No

Sequence Available

No

Original Discovery Method

Phage display technology

Antibody/Binder Origins

Animal-dependent discovery, post-2020, In vitro recombinant expression