Description
SARS-CoV-2 Spike Protein (S1) (E5S3V) Rabbit mAb recognizes endogenous levels of total SARS-CoV-2 spike protein. The antibody detects full-length SARS-CoV-2 spike protein and also detects the S1 domain generated by furin cleavage. The antibody has been confirmed to detect the following SARS-CoV-2 isolates and variants: USA-WA1/2020, Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2), and Omicron (B.1.1.529). The antibody does not cross-react with spike proteins from SARS or MERS coronaviruses. Non-specific nuclear foci staining was observed in some mouse tissues by immunohistochemistry. Monoclonal antibody is produced by immunizing animals with recombinant protein corresponding to the S1 domain of SARS-CoV-2 spike protein (USA-WA1/2020 isolate).
Target
Spike Protein SARS-CoV-2
Target Alias Names
S, Spike Glycoprotein
Isotype/Mimetic
IgG
Animal-Derived Biomaterials Used
BSA
Sequence Available
Yes
Original Discovery Method
Immunization
Antibody/Binder Origins
Animal-dependent discovery, post-2020, In vitro recombinant expression, Animal-derived biomaterials used in production or final formulation