Antibodies under a microscope

110922-R0061

Phospho-Tau (Thr217) Antibody, Rabbit MAb

Description

MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are mostly found in neurons compared to non-neuronal cells. One of tau's main functions is to modulate the stability of axonal microtubules. Other nervous system MAPs may perform similar functions, as suggested by tau knockout mice, who did not show abnormalities in brain development - possibly because of compensation in tau deficiency by other MAPs.

Target

MAPT

Target Alias Name

MAPT

Isotype/Mimetic

Rabbit IgG

Animal-Derived Biomaterials Used

No

Sequence Available

No

Original Discovery Method

Phage display technology

Antibody/Binder Origins

Animal-dependent discovery, post-2020, In vitro recombinant expression