Description
Bcl-2 agonist of cell death (BAD) is a BH3-only member of the Bcl-2 family which possesses important regulatory function in apoptosis. BAD has also been shown to possess many non-apoptotic functions closely linked to cancer including regulation of glycolysis, autophagy, cell cycle progression and immune system development. Oral squamous cell carcinoma (OSCC) is a type of cancer with high morbidity and mortality rates worldwide; it also demonstrates chemotherapeutic resistance. Triterpenoid ursolic acid has been shown to exhibit various biological activities and anticancer effects in several preclinical studies. The apoptosis associated signaling showed that ursolic acid decreased the phosphorylation of AKT (Ser473) and B cell lymphoma 2 (Bcl 2) associated agonist of cell death (BAD; Ser136), and the protein levels of Bcl 2 and Bcl extra large (Bcl xL), and increased the expression of BAD and Bcl 2 associated X (Bax) protein in CAR cells.
Target
Bad
Target Alias Name
Bad
Isotype/Mimetic
Rabbit IgG
Animal-Derived Biomaterials Used
No
Sequence Available
No
Original Discovery Method
Phage display technology
Antibody/Binder Origins
Animal-dependent discovery, post-2020, In vitro recombinant expression