Description
Pan-Keratin (Type I) (E6S1S) Rabbit mAb (Alexa Fluor® 750 Conjugate) recognizes endogenous levels of total type I keratin protein. The antibody was validated to detect overexpressed keratin 10, 17, and 18. By homology, it is also predicted to detect keratin 13, 14, 15, 16, and 19. It does not detect type II keratins including keratin 1, 5, 6a, 7, and 8. Non-specific staining was observed in Leydig cells of the testis by immunohistochemistry. Monoclonal antibody is produced by immunizing animals with a mix of synthetic peptides corresponding to residues highly conserved among type I keratins.
Targets
K10 mouse, K18 mouse, K14 mouse, K15 mouse, K16 mouse, K17 mouse, K19 mouse
Target Alias Names
Krt10, Krt18, Krt14, Krt15, Krt16, Krt17, Krt19, K10, K18, K14, K15, K16, K17, K19
Isotype/Mimetic
IgG
Animal-Derived Biomaterials Used
BSA
Sequence Available
Yes
Original Discovery Method
Immunization
Antibody/Binder Origins
Animal-dependent discovery, post-2020, In vitro recombinant expression, Animal-derived biomaterials used in production or final formulation