Description
Provided is humanized antibody, h82D6A3, by variable domain resurfacing and grafting on the constant regions of a human IgG4. The h82D6A3 still binding with high affinity to VWF and retained the inhibitory properties of the murine 82D6A3.
Target
VWF
Target Alias Names
VWD, F8VWF
Isotype/Mimetic
Humanized IgG4
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression