Description
The affinity matured antibodies XPA.10.064.03, XPA.10.064.04, XPA.10.064.06, XPA.10.064.07, and XPA.10.064.10 as provided herein were generated by random mutagenesis of XPA.10.064 HCDR3 and subsequent binding and functional assays. The binding affinities of the affinity matured antibodies for hVEGF165 are greater than that of Bevacizumab.
Target
VEGFA
Target Alias Names
Vascular Endothelial Growth Factor A, Vascular Permeability Factor, VEGF, VPF, Vascular Endothelial Growth Factor A121, Vascular Endothelial Growth Factor A165, Vascular Endothelial Growth Factor, VEGF-A, MVCD1
Isotype/Mimetic
Human IgG2
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression