Description
This is a human monoclonal antibody that specifically binds to VCAM-1. 7H shows a strong affinity to VCAM-1 expressed on human or mouse endothelial cell, effectively inhibits leukocyte adhesion to activated endothelial cells expressing VCAM-1, and shows a low immunogenicity, thereby can be used for the treatment of cancer or inflammatory disease.
Target
VCAM1
Target Alias Names
Vascular Cell Adhesion Molecule 1, CD106 Antigen, INCAM-100, Vascular Cell Adhesion Protein 1, V-CAM 1, VCAM-1, CD106
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression