Description
TPI is glycolytic enzyme essential for efficient energy production and are expressed in all prokaryotic and eukaryotic organisms. TPI and GAPDH have been considered to associate with brain microtubules. The anti-TPI or anti-GAPDH Abs may induce an immune hypersensitivity reaction, through activation of complements and macrophages, leading to neuronal and axonal degeneration in MS.
Target
TPI 1
Target Alias Names
TIM, TPI, TPID, HEL-S-49
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression