Description
This product is a recombinant human antibody that recognizes human DR5 and does not bind to the closest human homologs from the TNFR superfamily such as DR4, decoy receptors (DcRl and DcR2) and osteoprotegerin (OPG). The antibody is cross-reactive with human and cynomolgus DR5 but do not recognize the murine counterpart. The antibody was expressed in mammalian cells with chemically defined culture media and was purified by affinity chromatography.
Target
TNFRSF10B
Target Alias Names
DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5
Isotype/Mimetic
Humanized IgG1
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression