Description
Recombinant Human Antibody (BDF1) is capable of binding to TNFRSF10B, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-TNFRSF10B mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-TNFRSF10B mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Target
TNFRSF10B
Target Alias Names
TNFRSF10B, tumor necrosis factor receptor superfamily, member 10b, DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5, tumor necrosis factor receptor superfamily member 10B, Fas-like protein, death receptor 5, cytotoxic TRAIL receptor-2, TNF receptor superfamily member 10b, apoptosis inducing receptor TRAIL-R2, apoptosis inducing protein TRICK2A/2B, TNF-related apoptosis-inducing ligand receptor 2, death domain containing receptor for TRAIL/Apo-2L, tumor necrosis factor receptor-like protein ZTNFR9, p53-regulated DNA damage-inducible cell death receptor(killer)
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression