Description
Humanized anti-RSPO3 antibody h131R007 has stronger inhibitors of β-catenin activity. h131R007 blocks binding of RSPO3 to LGR5.
Target
RSPO3
Target Alias Names
RSPO3, R-spondin 3, PWTSR, THSD2, CRISTIN1, R-spondin-3, R-spondin 3 homolog, roof plate-specific spondin-3, protein with TSP type-1 repeat, thrombospondin, type I, domain containing 2, thrombospondin type-1 domain-containing protein 2
Isotypes/Mimetics
Humanized IgG2, κ
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression