Description
Provided herein is a chimeric antibody ch11C10 that binds to human RSPO3, cyno RSPO3 and murine RSPO3 with a Kd of less than 0.5 nM. The antibody has a half-life of at least 6 days and reduce tumor growth.
Target
RSPO3
Target Alias Names
R-Spondin 3, Thrombospondin Type-1 Domain-Containing Protein 2, Thrombospondin, Type I, Domain Containing 2, Protein With TSP Type-1 Repeat, Roof Plate-Specific Spondin-3, THSD2, PWTSR
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression