Description
Provided is an anti-ROBO4 antibody cMAb1-1. cMAb1-1 was derived from the mice that immunized with rROBO4-ECD. The antibody activates the downstream signal of ROBO4 and has suppressive activity against cell migration induced by VEGF or bFGF. The antibody also exhibits an anti-angiogenesis effect in in-vivo models.
Target
ROBO4
Target Alias Names
Roundabout Guidance Receptor 4, Magic Roundabout, Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila), Roundabout, Axon Guidance Receptor, Homolog 4, Roundabout Homolog 4, Magic Roundabout, Roundabout Homolog 4 (Drosophila), Roundabout Homolog 4, ECSM4, MRB
Isotype/Mimetic
Chimeric (mouse/human) IgG1
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression