Description
Disclosed are antibodies that bind to Prominin-1 and have ADCC activity and CDC activity. Recombinant antibodies were produced by cloning a nucleotide sequence of the AC133 antibody variable region and it was discovered that the ADCC/CDC-inducing effect which does not exist in the original AC133 antibody is imparted to the recombinant antibodies.
Target
PROM1
Target Alias Names
PROM1, prominin 1, RP41, AC133, CD133, MCDR2, STGD4, CORD12, PROML1, MSTP061, prominin-1, hProminin, antigen AC133, prominin-like protein 1, hematopoietic stem cell antigen
Isotype/Mimetic
Humanized IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression