Description
GBR-VH5(V37A)VL1(*) is a humanized anti-TrkA antibody with enhanced inhibitory properties comprising a heavy chain variable region, a light chain variable region, a human light chain constant region and a variant human IgG4 heavy chain constant region (IGHG4 isotype with S228P substitution) which exhibit altered exchange properties.
Target
NTRK1
Target Alias Names
MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA
Isotypes/Mimetics
Humanized IgG4, κ
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression