Description
An engineered antibody derived from BXhVH5VL1. A simple change of valine to alanine (mouse back-mutation) in the heavy chain variable domain at position 37 led to a potency increase in TF-1 cell proliferation assays for the variant GBR-VH5 (V37A)VL1, with a ten-fold increase in comparison to the BXhVH5VL1 humanized antibody.
Target
NTRK1
Target Alias Names
MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA
Isotypes/Mimetics
Humanized IgG1, κ
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression