Description
The c-mpl agonist antibody is shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocytes and megakaryocyte progenitor cells. Accordingly, the antibody may be used for treatment of thrombocytopenia.
Target
MPL
Target Alias Names
MPL Proto-Oncogene, Thrombopoietin Receptor, Myeloproliferative Leukemia Virus Oncogene, Myeloproliferative Leukemia Protein, Proto-Oncogene C-Mpl, TPO-R, TPOR, Thrombopoietin Receptor
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression