Description
Provided is an antibody capable of binding to human MICA polypeptides. The antibody has increased activity in the treatment of disorders characterized by MICA-expressing cells, particularly cancer. mAb1 and mAb2 showed a particularly strong improvement in binding affinity for MICA alleles *01, *04 and *07.
Target
MICA
Target Alias Names
MHC Class I Polypeptide-Related Sequence A, PERB11.1, MIC-A, Truncated MHC Class I Polypeptide-Related Sequence A, MHC Class I Chain-Related Protein A, Stress Inducible Class I Homolog, MHC Class I Related Sequence A, MHC Class I Related Chain A, HLA Class I Antigen
Isotype/Mimetic
Human IgG1
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression