Description
Recombinant Human Antibody (5D5) is capable of binding to MET, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-MET mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-MET mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody potently inhibits HGF binding and receptor phosphorylation and signaling and has antibody-like pharmacokinetics and antitumor activity.
Target
MET
Target Alias Names
MET, MET proto-oncogene, receptor tyrosine kinase, HGFR, AUTS9, RCCP2, c-Met, hepatocyte growth factor receptor, SF receptor, HGF receptor, HGF/SF receptor, proto-oncogene c-Met, scatter factor receptor, tyrosine-protein kinase Met, met proto-oncogene tyrosine kinase
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression