Description
Recombinant Human Antibody (HP1/2) is capable of binding to α4 integrin, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-α4 integrin mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-α4 integrin mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Target
ITGA4
Target Alias Names
ITGA4, integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor), IA4, CD49D, integrin alpha-4, 269C wild type, integrin alpha 4, integrin alpha-IV, VLA-4 subunit alpha, integrin alpha-4 subunit, CD49 antigen-like family member D, antigen CD49D, alpha-4 subunit of VLA-4 receptor, very late activation protein 4 receptor, alpha 4 subunit
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression