Description
This product is a chimeric (mouse/human) antibody targeting human IGF-1R. This antibody blocked the binding of IGF-I and IGF-II to IGF-IR, and inhibited both IGF-I and IGF-II induced phosphorylation of IGF-IR in MCF-7 cells. This antibody could be an useful antibody in diagnosis and treatment of cancer, as well as a research tool.
Target
IGF1R
Target Alias Names
IGFR, CD221, IGFIR, JTK13
Isotype/Mimetic
Human IgG1
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression