Description
Recombinant Human Antibody (AIFNα1b) is capable of binding to IFNA1/13, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-IFNA1/13 mAb and CH1-3 region of human IgG and a light chain (LC) encoding VL from anti-IFNA1/13 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody shares partial epitopes of IFNα1b with its receptor IFNAR2 but with much higher binding affinity to IFNα1b than IFNAR2 and exhibits its neutralizing activity through competition with IFNAR2 to bind with IFNα and prevents the activation of IFNα-mediated signaling pathway.
Target
IFNA1 / IFNA13
Target Alias Names
IFNA1, interferon, alpha 1, interferon alpha-1/13, IFL, IFN, IFN ALPHA
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression