Description
This product is a human antibody derived from phage display library targeting human HLA-DR. This antibody binds HLA-DR on the CD4 binding site instead of interfering with interaction of HLA-DR with cognate T cell receptor (TCR). It may induce conformational and/or spatial changes in the HLA-DR molecule hence preventing the interaction between HLA-DR and cognate T cell receptor or between HLA-DR and the T cell co-receptor CD4.
Target
HLA-DR
Target Alias Names
DR alpha chain precursor, DRB1, DRB4, HLA class II histocompatibility antigen, HLA class II histocompatibility antigen DR alpha chain, HLA DR1B, HLA DR3B, HLA DRA
Isotype/Mimetic
Human IgG1
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression