Description
Recombinant Human Antibody (8FAB) is capable of binding to Hepcidin, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-Hepcidin mAb and CH1 region of human IgG1 and a light chain (LC) encoding VL from anti-Hepcidin proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Target
Hepcidin
Target Alias Names
HAMP, hepcidin antimicrobial peptide, HEPC, PLTR, HFE2B, LEAP1, hepcidin, putative liver tumor regressor, liver-expressed antimicrobial peptide 1
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression