Description
Provided are antibodies that specifically bind to human histidyl-tRNA synthetase. The antibody can be used for treating cancer, including as standalone therapies or in combination with cancer immunotherapies, for example, immune checkpoint modulators such as PD-1 inhibitors.
Target
HARS
Target Alias Names
Histidyl-TRNA Synthetase, EC 6.1.1.21, HisRS, HRS, Histidine TRNA Ligase 1, Cytoplasmic, Histidine--TRNA Ligase, Cytoplasmic
Isotypes/Mimetics
Human IgG4, κ
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression