Description
This product is a Human antibody that recognizes Human FZD7. F7.B bound FZD1, -2, -4, -5, -7, and -8 on the cell surface, but did not bind FZD3, -6, -9, or -10. F7.B showed cross-reactivity to mouse FZD4 and FZD5. F7.B functionally inhibited Wnt3a-induced β-catenin stabilization in 32D cells expressing each of their respective FZD-binding partners.
Target
FZD7
Target Alias Names
FzE3, frizzled-7, Frizzled, drosophila, homolog of, 7, frizzled 7, seven transmembrane spanning receptor, frizzled family receptor 7, frizzled homolog 7, fz-7, hFz7, Frizzled class receptor 7, cysteine-rich domain, CRD
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression