Description
Recombinant Human Antibody (R3Mab) is capable of binding to FGFR3, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-FGFR3 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-FGFR3 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody inhibited not only WT FGFR3, but also various mutants of the receptor.
Target
FGFR3
Target Alias Names
FGFR3, fibroblast growth factor receptor 3, ACH, CEK2, JTK4, CD333, HSFGFR3EX, FGFR-3, tyrosine kinase JTK4, hydroxyaryl-protein kinase, fibroblast growth factor receptor 3 variant 4
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression