Description
Recombinant monoclonal antibody specially binds to A3-C1 domains of factor VIII. This human anti-F8 antibody (KM38) is not directed against amino acid residues E1649-R1689, a recently described epitope for factor VIII inhibitors in the acidic region at the amino-terminus of the factor VIII light chain. The epitope of this product overlaps with that of antibody CLB-CAg 12, a noninhibitory mAb directed against the A3-C1 domains of factor VIII.
Target
F8
Target Alias Names
AHF, F8B, F8C, HEMA, FVIII, DXS1253E
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression