Description
The monoclonal antibody KM33 acts as a high-affinity ligand that can inhibit the function of blood coagulation factor VIII (FVIII). In vitro, KM33 inhibits FVIII activity and interactions with its physiological ligands, von Willebrand factor, phospholipids and catabolic receptors.
Target
F8
Target Alias Names
Coagulation Factor VIII, Coagulation Factor VIII, Procoagulant Component, Antihemophilic Factor, F8C, AHF, Coagulation Factor VIII A1 Domain, Coagulation Factor VIII C2 Domain, Coagulation Factor VIIIc, Procoagulant Component, Factor VIII F8B, Factor VIIIF8B, Hemophilia A, DXS1253E, FVIII, HEMA, F8B
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression