Description
Provided is an antibody which recognizes the exosite 1 epitope of thrombin and selectively inhibit thrombin without promoting bleeding. The antibody may be useful in the treatment and prevention of thrombosis, embolism and other conditions mediated by thrombin.
Target
F2
Target Alias Names
Coagulation Factor II, Thrombin, Prepro-Coagulation Factor II, EC 3.4.21.5, Coagulation Factor II (Thrombin), Coagulation Factor II, Prothrombin B-Chain, Serine Protease
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression