Description
Recombinant Human Antibody (KTN3379) is capable of binding to ERBB3, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-ERBB3 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-ERBB3 mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. The inhibitory ErbB3 antibody blocks both NRG-dependent and-independent mechanisms of activation by binding to a novel epitope.
Target
ERBB3
Target Alias Names
ERBB3, erb-b2 receptor tyrosine kinase 3, HER3, LCCS2, ErbB-3, c-erbB3, erbB3-S, MDA-BF-1, c-erbB-3, p180-ErbB3, p45-sErbB3, p85-sErbB3, receptor tyrosine-protein kinase erbB-3, proto-oncogene-like protein c-ErbB-3, human epidermal growth factor receptor 3, tyrosine kinase-type cell surface receptor HER3, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression