Description
This product is a recombinant humanized antibody that recognizes ERBB2, which is overexpressed in cancer cells such as breast cancer and gastric cancer cells. An extracellular domain (ECD) site of HER2 protein used as an antigen. The antibody binds to sub-domain 4 of the ECD of the ERBB2 protein, an different epitope from trastuzumab. The antibody was expressed in mammalian cells with chemically defined culture media and was purified by affinity chromatography.
Target
ERBB2
Target Alias Names
Erb-B2 Receptor Tyrosine Kinase 2, V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2, Tyrosine Kinase-Type Cell Surface Receptor HER2, Neuro/Glioblastoma Derived Oncogene Homolog, Human Epidermal Growth Factor Receptor 2, Metastatic Lymph Node Gene 19 Protein, Proto-Oncogene C-ErbB-2, Proto-Oncogene Neu, EC 2.7.10.1, P185erbB2, MLN 19, HER2, NGL, NEU, V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2 (Neuro/Glioblastoma Derived Oncogene Homolog)
Isotypes/Mimetics
Humanized IgG1, κ
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression