Description
The antibody (D2-1A7) is an internalizing antibody that specifically binds to the tumor associated antigen EphA2. Antibody D2-1A7 was identified as a ligand blocking scFv that is strongly internalized by cells expressing EphA2.
Target
EPHA2
Target Alias Names
EPH Receptor A2, Tyrosine-Protein Kinase Receptor ECK, EC 2.7.10.1, ECK, Epithelial Cell Receptor Protein Tyrosine Kinase, Ephrin Type-A Receptor 2, Soluble EPHA2 Variant 1, Epithelial Cell Kinase
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression