Description
The agonistic EphA2 antibody 2A4 is affinity matured from humanized mAb 4H5, which is humanized form murine antibody EA2. 2A4 demonstrates marked improvements in binding affinities to EphA2 as compared to EA2 and 4H5.
Target
EPHA2
Target Alias Names
EPH Receptor A2, Tyrosine-Protein Kinase Receptor ECK, EC 2.7.10.1, ECK, Epithelial Cell Receptor Protein Tyrosine Kinase, Soluble EPHA2 Variant 1, Epithelial Cell Kinase, EC 2.7.10, CTRCT6, ARCC2, CTPP1, EphA2, CTPA
Isotype/Mimetic
Humanized IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression