Description
This is a fully human monoclonal antibody directed to CD105. The antibody 6B10 can inhibit vessel lengthening by at least 20%, and can cause pronounced modulation of the actin cytoskeleton structure of endothelial cells.
Target
ENG
Target Alias Names
Endoglin, CD105 Antigen, END, Osler-Rendu-Weber Syndrome 1, HHT1, ORW1
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression