Description
This is a human pemphigus vulgaris monoclonal autoantibodies isolated by phage display. The clone (D3)3c/9, although selected for binding against only hDsg3, also demonstrates weak binding to hDsg1. Howerver, (D3)3c/9 shows different binding pattern on mouse epidermis, which recognizes only mDsg3 and not mDsg1.
Target
DSG3
Target Alias Names
Desmoglein 3, 130 KDa Pemphigus Vulgaris Antigen, Cadherin Family Member 6, CDHF6, PVA, Desmoglein 3 (Pemphigus Vulgaris Antigen), Pemphigus Vulgaris Antigen
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression