Description
The product is a recombinant antibody that specifically bind DKK1 polypeptides. The binding region for the mAb includes two discontinuous portions, the first from amino acids 98 to 104 and a region from amino acids 107-121 and 127-140. The antibody can bind to DKK1 to protect all cleavage sites on D1 domain from trypsin proteolysis.
Target
DKK1
Target Alias Names
Dickkopf WNT Signaling Pathway Inhibitor 1, HDkk-1, DKK-1, SK, Dickkopf (Xenopus Laevis) Homolog 1, Dickkopf 1 Homolog (Xenopus Laevis), Dickkopf Related Protein-1, Dickkopf-Like Protein 1, Dickkopf 1 Homolog, Dickkopf-1 Like, Dickkopf-1
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression