Description
An isolated antibody (HY29) specifically binds to CXC chemokine receptor-2 (CXCR2), wherein the binding molecule can inhibit binding to interleukin 8 (IL-8). Mapping of the N terminus using linear peptides and alanine scanning of CLIPS peptides derived from the N terminus and ECL3 showed that the minimal epitope for the antibody binding was centered around the 31 PFLLD 35 with the second leucine and the aspartic acid key to the binding interaction.
Target
CXCR2
Target Alias Names
CXCR2, chemokine (C-X-C motif) receptor 2, CD182, IL8R2, IL8RA, IL8RB, CMKAR2, CDw128b, C-X-C chemokine receptor type 2, CXC-R2, CXCR-2, IL-8R B, GRO/MGSA receptor, IL-8 receptor type 2, interleukin 8 receptor B, chemokine (CXC) receptor 2, interleukin 8 receptor, beta, interleukin 8 receptor type 2, interleukin-8 receptor type B, CXCR2 gene for IL8 receptor type B, high affinity interleukin-8 receptor B
Isotype/Mimetic
Humanized IgG1
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression