Description
This product is a recombinant human antibody that is designed to target cytotoxic T lymphocyte antigen-4. Through its mechanism of action, the antibody has demonstrated a notable increase in T cell activation. Furthermore, it functions by inhibiting the interaction between CTLA4 and human B7, specifically targeting the binding of CTLA4 to human B7.1 and/or human B7.2.
Target
Cytotoxic T lymphocyte antigen-4
Target Alias Names
Cytotoxic T-Lymphocyte Associated Protein 4, Insulin-Dependent Diabetes Mellitus 12, Celiac Disease 3, CTLA-4, CD152, Ligand And Transmembrane Spliced Cytotoxic T Lymphocyte Associated Antigen 4, Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form, Cytotoxic T-Lymphocyte-Associated Serine Esterase-4, Cytotoxic T-Lymphocyte-Associated Antigen 4, Cytotoxic T-Lymphocyte Protein 4
Isotypes/Mimetics
Humanized IgG1, κ
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression