Description
Recombinant Human Antibody (MB007) is capable of binding to GM-CSF, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-GM-CSF mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-GM-CSF proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This is a high-affinity anti-(human GM-CSF) autoantibody isolated from a patient suffering from PAP which shows only modest neutralization of GM-CSF bioactivity.
Target
CSF2
Target Alias Names
CSF2, colony stimulating factor 2 (granulocyte-macrophage), GMCSF, granulocyte-macrophage colony-stimulating factor, CSF, molgramostin, sargramostim, granulocyte macrophage-colony stimulating factor
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression