Description
Recombinant Human Antibody (AFD) is capable of binding to CFD, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-CFD mAb and CH1-3 region of human IgG and a light chain (LC) encoding VL from anti-CFD proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. AFD inhibits FD proteolytic function by interfering with macromolecular substrate access rather than by inhibiting FD catalysis, providing the molecular basis of AFD-mediated inhibition of a rate-limiting step in the alternative complement pathway.
Target
CFD
Target Alias Names
CFD, complement factor D (adipsin), DF, ADN, PFD, ADIPSIN, complement factor D, properdin factor D, C3 convertase activator, complement factor D preproprotein, D component of complement (adipsin)
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression