Description
This product is a neutralizing human CD47 antibody derived from hybridomas. antibody used in various therapeutic approaches, CD47 is a ubiquitously expressed transmembrane glycoprotein with a single Ig-like domain and five transmembrane regions that serves as a cellular ligand for SIRPa through the NH2-terminal V-like structure of SIRPa Domain mediates binding.
Target
CD47
Target Alias Names
CD47 Molecule, Antigenic Surface Determinant Protein OA3, CD47 Antigen (Rh-Related Antigen, Integrin-Associated Signal Transducer), Antigen Identified By Monoclonal Antibody 1D8, Leukocyte Surface Antigen CD47, Integrin Associated Protein, Rh-Related Antigen, CD47 Glycoprotein
Isotype/Mimetic
Humanized IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression