Description
The product is a human isotype and agonistic antibody that binds to human CD40. It has the ability to induce an increase in the expression of CD95 on the cell surface. The encoded protein is a receptor on antigen-presenting cells of the immune system and is critical for mediating multiple immune and inflammatory responses, including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40-related disorders include hyper-Igm immunodeficiency, type 3, and hyper-Igm immunodeficiency, type 1.
Target
Cluster of differentiation 40
Target Alias Names
CD40 Molecule, CD40 Molecule, TNF Receptor Superfamily Member 5, CD40L Receptor, TNFRSF5, CDW40, Bp50, Tumor Necrosis Factor Receptor Superfamily, Member 5
Isotype/Mimetic
Human IgG
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression