Description
The product binds to human CD40 with an affinity of 0.237 nM. It exhibits blocking activity against human CD40 at a concentration of 1 μg/mL. The CD4 antigen acts as a coreceptor in conjunction with the T cell receptor on T lymphocytes to recognize antigens displayed by antigen-presenting cells in the context of class II MHC molecules. CD4-related diseases include immunodeficiency 79 and Okt4 epitope deficiency.
Target
CD40
Target Alias Names
CD40 Molecule, CD40 Molecule, TNF Receptor Superfamily Member 5, CD40L Receptor, TNFRSF5, CDW40, Bp50, Tumor Necrosis Factor Receptor Superfamily, Member 5
Isotypes/Mimetics
Human IgG4, κ
Animal-Derived Biomaterials Used
None
Sequence Available
No
Original Discovery Method
Human-derived phage display
Original Discovery Information Provided On Datasheet
No
Antibody/Binder Origins
Animal-free discovery, In vitro recombinant expression